Professor Imai received his MD and PhD degrees from Keio University School of Medicine in Tokyo, Japan. During his postdoctoral period at the Massachusetts Institute of Technology, he made a paradigm-shifting discovery of the NAD+-dependent protein deacetylase activity of yeast and mammalian Sir2 proteins and published his landmark paper in Nature in 2000. In 2001, he joined the faculty of Washington University School of Medicine and is currently a Professor of Developmental Biology and Medicine. His laboratory has been devoted to studying the roles of mammalian SIRT1 and NAMPT-mediated NAD+ biosynthesis in the systemic regulatory network for aging/longevity control in mammals. Based on his research, he has proposed a concept, named the “NAD World”, for mammalian aging/longevity control. Professor Imai’s long-term goal is to achieve “productive aging” by understanding the spatial and temporal dynamics of the NAD World and developing effective anti-aging interventions.
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