Cornelia M. Weyand, M.D., Ph.D., is Professor of Medicine and the Chief of the Division of Immunology and Rheumatology at Stanford University School of Medicine.
Dr. Weyand has a special interest in understanding how the human immune system ages and how this leads to inflammatory disease. The immune system protects against infections and malignancy and regulates the wound healing process. With progressive age, individuals become susceptible to cancer and infections. Unexpectedly, aging also leads to much higher risk for tissue inflammation. Dr. Weyand and her team have defined successful and maladaptive immune aging and are developing therapeutic strategies to slow down the immune aging process.
Together with her research team, Dr. Weyand has examined immune malfunction in two disease states, rheumatoid arthritis and vasculitis of the large blood vessels. In patients with rheumatoid arthritis the immune system ages much faster, loses protective functions and gains pro-inflammatory potential. Vasculitis of the large blood vessels leads to life-threatening complications and is strictly linked to the patient’s age. By examining immune cells from affected patients, Dr. Weyand’s group has defined mechanism of tissue invasion of inflammatory cells, arrest and survival signals that hold inflammatory cells in the tissue and the energy sources that allow inflammatory cells to fuel their bad behaviors.
« Go Back