Speakers Articles

Take a look at what our Big Questions in Neuroscience speakers have published recently and chat with them about their work in Arlington, USA this November.

Paola Arlotta, Harvard, USA

Cell diversity and network dynamics in photosensitive human brain organoids
The promises and challenges of human brain organoids as models of neuropsychiatric disease
Diversity Matters: A Revised Guide to Myelination
Adult axolotls can regenerate original neuronal diversity in response to brain injury
Homeotic Transformations of Neuronal Cell Identities
Instructing Perisomatic Inhibition by Direct Lineage Reprogramming of Neocortical Projection Neurons

Graeme Davis, UCSF, USA

The Global Challenge in Neuroscience Education and Training: The MBL Perspective
α2δ-3 Is Required for Rapid Transsynaptic Homeostatic Signaling
The Innate Immune Receptor PGRP-LC Controls Presynaptic Homeostatic Plasticity
VCP-dependent muscle degeneration is linked to defects in a dynamic tubular lysosomal network in vivo

Dan Geschwind, UCLA, USA

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program
The road to precision psychiatry: translating genetics into disease mechanisms
Chromosome conformation elucidates regulatory relationships in developing human brain
Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families
Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder

Chenghua Gu, Harvard Medical School, USA

Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis
Gradual Suppression of Transcytosis Governs Functional Blood-Retinal Barrier Formation
Temporal modulation of collective cell behavior controls vascular network topology
The molecular constituents of the blood-brain barrier
Neuronal and vascular interactions

Tamas Horvath, Yale Medical School, USA

Cannabinoid type 1 receptor-containing axons innervate NPY/AgRP neurons in the mouse arcuate nucleus
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Metabolism and Mental Illness
Hypothalamic POMC neurons promote cannabinoid-induced feeding

Elaine Hsiao, UCLA, USA

The Microbiome and Host Behavior
Interactions between the microbiota, immune and nervous systems in health and disease
Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders

Sabine Kastner, Princeton, USA

FEF-Controlled Alpha Delay Activity Precedes Stimulus-Induced Gamma-Band Activity in Visual Cortex
From Behavior to Neural Dynamics: An Integrated Theory of Attention
Probabilistic Maps of Visual Topography in Human Cortex
The Anatomical and Functional Organization of the Human Visual Pulvinar
Attention in the real world: toward understanding its neural basis

Jennifer Lippincott-Schwartz, Janelia Research Campus, USA

Applying systems-level spectral imaging and analysis to reveal the organelle interactome
AMPK and vacuole-associated Atg14p orchestrate µ-lipophagy for energy production and long-term survival under glucose starvation
Increased spatiotemporal resolution reveals highly dynamic dense tubular matrices in the peripheral ER
ER trapping reveals Golgi enzymes continually revisit the ER through a recycling pathway that controls Golgi organization
A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

Earl Miller, MIT, USA

Synchronous beta rhythms of frontoparietal networks support only behaviorally relevant representations
Gamma and Beta Bursts Underlie Working Memory
Prefrontal Cortex Networks Shift from External to Internal Modes during Learning
Stimulus Load and Oscillatory Activity in Higher Cortex
Cortical information flow during flexible sensorimotor decisions
Frequency-specific hippocampal-prefrontal interactions during associative learning

Kia Nobre, Oxford, UK

Temporal Expectations Guide Dynamic Prioritization in Visual Working Memory through Attenuated α Oscillations
Preparatory α-band oscillations reflect spatial gating independently of predictions regarding target identity
Retrospective Attention Interacts with Stimulus Strength to Shape Working Memory Performance
Apolipoprotein ɛ4 breaks the association between declarative long-term memory and memory-based orienting of spatial attention in middle-aged individuals
Temporal orienting of attention can be preserved in normal aging
Behavioral and Neural Markers of Flexible Attention over Working Memory in Aging
Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing

Josef Parvizi, Stanford, USA

Direct cortical stimulation of human posteromedial cortex
Electrophysiological Responses in the Ventral Temporal Cortex During Reading of Numerals and Calculation
Linking Electrical Stimulation of Human Primary Visual Cortex, Size of Affected Cortical Area, Neuronal Responses, and Subjective Experience
Mapping human temporal and parietal neuronal population activity and functional coupling during mathematical cognition
Decoding intracranial EEG data with multiple kernel learning method
Electrophysiological Responses in the Ventral Temporal Cortex During Reading of Numerals and Calculation
Functional asymmetry between the left and right human fusiform gyrus explored through electrical brain stimulation

David Rowitch, Cambridge, UK

A Sequentially Priming Phosphorylation Cascade Activates the Gliomagenic Transcription Factor Olig2
Olig1 is required for noggin-induced neonatal myelin repair
Functional diversity of astrocytes in neural circuit regulation
Oligodendrocyte-encoded HIF function couples postnatal myelination and white matter angiogenesis
Astrocyte-encoded positional cues maintain sensorimotor circuit integrity

Erin Schuman, Max Planck Institute, Germany

Activity-dependent spatially localized miRNA maturation in neuronal dendrites
Nascent Proteome Remodeling following Homeostatic Scaling at Hippocampal Synapses
Unconventional secretory processing diversifies neuronal ion channel properties
Circular RNAs in Brain and Other Tissues: A Functional Enigma
Direct visualization of newly synthesized target proteins in situ

Paul Taylor, St. Jude, USA

Decoding ALS: from genes to mechanism
C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles
Phase separation by low complexity domains promotes stress granule assembly and drives pathological fibrillization
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Gina Turrigiano, Brandeis, USA

The dialectic of Hebb and homeostasis
Neuronal Firing Rate Homeostasis Is Inhibited by Sleep and Promoted by Wake
Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway
Activity-dependent synaptic GRIP1 accumulation drives synaptic scaling up in response to action potential blockade

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