Karen received her PhD from the University of London and following postdoctoral fellowships at the ICR and NCI, she led research groups at the Ludwig Institute in London and the NCI. She moved back to the UK to become the Director of the CRUK Beatson Institute in Glasgow before returning to London to become Chief Scientist at CRUK and Group Leader at the Francis Crick Institute.
Karen's research has focused on the tumour suppressor protein p53. She has made contributions to our understanding of how p53 is regulated and the functions of p53 that contribute to its ability to control cancer progression. She revealed an unexpected ability of p53 to help cells adapt and survive under transient periods of nutrient starvation, work that has led to a more general investigation of cancer cell metabolism.
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