Dr. Pearce completed her doctoral training at the University of Pennsylvania in Philadelphia, focusing on the regulation of T cell responses during infection. She continued her postdoctoral studies at the University of Pennsylvania and it was during this time she began her research into how cellular metabolic processes govern the immune response to infection and cancer. In 2009 Dr. Pearce began her independent research career as an Assistant Member at the Trudeau Institute in Saranac Lake, NY. In 2011 she joined the faculty at Washington University in St. Louis and was promoted to Associate Professor in 2014. In September 2015, Dr. Pearce became a Director at the Max Planck Institute for Immunobiology and Epigenetics in Freiburg, Germany and Head of the Department of Immunometabolism. Her research continues to investigate the metabolic pathways in immune cells with a view to targeting these pathways for therapy.
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