Speakers Articles

Take a look at what some of our speakers have published recently and chat with them about their work in San Diego, USA.

Lisa Coussens, Oregon Health & Science University, USA
The Basis of Oncoimmunology
Alk5 inhibition increases delivery of macromolecular and protein-bound contrast agents to tumors

Juan R. Cubillos-Ruiz, Weill Cornell Medicine, USA
Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment

Gordon Freeman, Dana Farber Cancer Institute, USA
Learning from PD-1 Resistance: New Combination Strategies

Romina Goldszmid, National Institutes of Health, USA
Two Bugs a NOD Away from Improving Cancer Therapy Efficacy
Beating Cancer with a Gut Feeling

Gillian Griffiths, Cambridge Institute for Medical Research, UK
The cytotoxic T lymphocyte immune synapse at a glance

Mathias Heikenwälder, German Cancer Research Center, Germany
P(URI)fying Novel Drivers of NASH and HCC: A Feedforward Loop of IL17A via White Adipose Tissue
The Liver at the Nexus of Host-Microbial Interactions

Michael Karin, University of California, San Diego, USA
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells

NF-κB Restricts Inflammasome Activation via Elimination of Damaged Mitochondria

Guido Kroemer, INSERM, Institut Gustave Roussy, France
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance
Metabolic Control of Longevity

Max Krummel, University of California, San Francisco, USA
Critical Role for CD103(+)/CD141(+) Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma
Visualization of immediate immune responses to pioneer metastatic cells in the lung

Lewis Lanier, UCSF, USA
Activating Receptors for Self-MHC Class I Enhance Effector Functions and Memory Differentiation of NK Cells during Mouse Cytomegalovirus Infection
Natural Killer Cell Memory

Gerry Linette, University of Pennsylvania, USA
Cancer immunotherapy. A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

Crystal Mackall, Stanford University, California, USA
Reduction of MDSCs with All-trans Retinoic Acid Improves CAR Therapy Efficacy for Sarcomas
4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

Karolina Palucka, Jackson Laboratories, USA
The Basis of Oncoimmunology

Erika Pearce, Max Planck Institute of Immunobiology and Epigenetics, Germany
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Gabriel Rabinovich, CONICET, Argentina
Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer

Michel Sadelain, Memorial Sloan Kettering Cancer Center, USA
Structural Design of Engineered Costimulation Determines Tumor Rejection Kinetics and Persistence of CAR T Cells

Erik Sahai, The Francis Crick Institute, UK
Cdc42EP3/BORG2 and Septin Network Enables Mechano-transduction and the Emergence of Cancer-Associated Fibroblasts
Intravital imaging reveals how BRAF inhibition generates drug-tolerant microenvironments with high integrin β1/FAK signalling

Caetano Reis e Sousa, The Francis Crick Institute, UK
Alive but Confused: Heterogeneity of CD11c(+) MHC Class II(+) Cells in GM-CSF Mouse Bone Marrow Cultures
Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

Jenny Ting, University of North Carolina at Chapel Hill, USA
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
The Innate Immune Receptor NLRX1 Functions as a Tumor Suppressor by Reducing Colon Tumorigenesis and Key Tumor-Promoting Signals

John Wherry, University of Pennsylvania, USA
Epigenetic stability of exhausted T cells limits durability of reinvigoration by PD-1 blockade
Costimulatory and Coinhibitory Receptor Pathways in Infectious Disease
Combination Cancer Therapies with Immune Checkpoint Blockade: Convergence on Interferon Signaling

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