Dr. Michael Diamond is The Herbert S. Gasser Professor in the Departments of Medicine, Molecular Microbiology, Pathology & Immunology and the Associate Director of the Center for Human Immunology and Immunotherapy Programs at Washington University School of Medicine. He received his MD and PhD degrees from Harvard Medical School and Harvard University. He completed his post-doctoral training at the University of California, Berkeley, and his internship, residency, and fellowship in infectious diseases at the University of California, San Francisco. He is an elected member of the Association of American Physicians, American Academy of Microbiology, and the American Society of Clinical Investigation. His current research focuses on the interface between viral pathogenesis and the host immune response. Many globally important human pathogens are studied including West Nile encephalitis, Zika, Dengue hemorrhagic fever, Venezuelan equine encephalitis, and Chikungunya viruses.
The Diamond laboratory investigates mechanisms of pathogenesis of emerging viruses of global concern. Novel interdisciplinary approaches are used to explore the interface between the virus and host with particular interest in understanding cell- and tissue-specific antiviral immune responses, especially in the brain. Genetic screens, systems biology, and immunological methods are applied to define how viruses cause disease in different tissues and how the host limits this process or in some cases, contributes to pathogenesis. The Diamond laboratory tests hypotheses for physiological relevance in newly generated transgenic animal models and conduct detailed analyses at the molecular, cellular, and organism level. They also explore how viruses evolve rapidly to evade host innate and adaptive immune responses yet maintain fitness. Finally, studies on the structural, molecular, and cellular basis of antibody neutralization of viruses have spurred vaccine and antibody-based therapeutic development. In summary, the Diamond laboratory focuses on both the virus and the host to define basic mechanisms of viral pathogenesis, host immunity, and cellular homeostasis, which can be utilized to mitigate disease..
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