Juleen R. Zierath is presently Professor of Clinical Integrative Physiology and Head of the Section of Integrative Physiology at the Dept. of Molecular Medicine and Surgery and the Dept. of Physiology and Pharmacology at Karolinska Institutet, Stockholm Sweden. She is also appointed Professor of Integrative Physiology at University of Copenhagen, where she is a Scientific Director at the Novo Nordisk Foundation Center for Metabolic Research.
Professor Zierath’s research has provided evidence for the physiological regulation of insulin signaling pathways in skeletal muscle, revealing key steps are impaired in diabetic patients. Her team discovered that reductions protein abundance of specific diacylglycerol kinase isoforms induces peripheral insulin resistance in Type 2 diabetes. As an exercise physiologist, she has a long-standing interest in the health promoting benefits of physical exercise. Her team has unraveled mechanisms by which exercise improves glucose metabolism and gene expression in diabetic patients. Recent work in her laboratory is directed towards understanding the link between diet and exercise in the development of insulin resistance through epigenetic modifications at the level of DNA methylation. The ultimate goal of her work is to identify and validate molecular candidates to prevent or treat insulin resistance in type 2 diabetes. Improving insulin sensitivity should alleviate diabetic complications and enrich the quality of life for the diabetic patient.
She is currently director of the Strategic Program in Diabetes at Karolinska Institutet and Chairman of the Board of Directors of the Keystone Symposia. Professor Zierath is currently Editor-in-Chief of Diabetologia and member of the Executive Committee of the European Association for the Study of Diabetes.
Professor Zierath is a member of the Royal Swedish Academy of Sciences, member of the Nobel Assembly and the Chairman of the Nobel Committee at Karolinska Institutet.
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