David Hyman is Chief of Early Drug Development at Memorial Sloan Kettering Cancer Center. He leads a large multidisciplinary group of researchers and physicians to conduct a variety of early phase clinical studies including first-in-human studies, novel combinations of investigational therapy, and histology-independent, molecularly selected “basket” studies. Under his direction, this service enrolls approximately 300 patients each year to a clinical trial portfolio of 40 early phase studies. In addition to conducting first-in-human studies, Dr. Hyman’s personal research has focused on the development of genomically selected targeted therapies. In particular, Dr. Hyman has helped to pioneer the use of multi-histology, genomically selected, “basket” studies which select patients based on the mutations harbored in their cancer rather than where the cancer came from. Dr. Hyman led the first-in-kind basket study that evaluated vemurafenib in BRAFV600 mutant cancers and published his initial findings in the New England Journal of Medicine. Dr. Hyman also led global development of larotrectinib in TRK-fusion positive cancers, establishing this as the first ever targeted therapy to be highly efficacious in tumor agnostic manner, also publishing these results in the New England Journal of Medicine. Dr. Hyman also published the results of another basket study of in ERBB2 mutant cancers in Nature, one of the first clinical trials ever published in this journal. Dr. Hyman has published extensively on the design and conduct of precision medicine and basket studies as well as their utility and limitations in multiple journals including Cell, Cancer Discover, JCO and PLOS Medicine. Dr. Hyman’s translational research is focused on understanding how the consequences of pathway inhibition vary as a function of tumor cell lineage and the complement of co-mutations within tumor cells. Dr. Hyman also has clinical expertise in gynecological cancers with a special interest in treating women with uterine sarcomas.
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