Our research broadly investigates how mechanisms that support tissue homeostasis in peripheral tissues may impact immune surveillance of barriers, including surveillance to cancers. My research includes understanding the molecular underpinnings of T cell tolerance (characterizing the GRAIL gene), and studying human and mouse dendritic cell (DC) biology as related to vaccine science, immune surveillance in peripheral tissue, and outcomes of tolerance or immunity for cancer immunotherapy. We use native human tissues/cells and relevant pre-clinical murine models to investigate the balance between tolerance and protective immunity, and tissue-specific mechanisms supporting tumor immune escape. I see patients in clinic one day per week, including those with melanoma skin cancer.
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