The Spitzer lab focused on understanding how various factors—including genetics, environment and pathology—impact the immune state. During his training in Immunology, Matt developed the experimental and computational framework necessary to interrogate the global state of immune system behavior, resulting in the development of the first immune system reference map. He has furthermore developed novel strategies for inducing immune-mediated tumor rejection and modeled their mechanisms using single-cell data. His laboratory at UCSF opened in 2016 in the Department of Microbiology and Immunology and is part of the Parker Institute for Cancer Immunotherapy and the Helen Diller Family Comprehensive Cancer Center. Projects in the lab currently focus on understanding how the immune state impacts the immune response to tumors, including the effects of cancer immunotherapies, as well as infectious disease. Another topic of interest is how pathologies, such as cancer, impact decision-making processes within the immune system.
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