Hongbo Chi, PhD, received his PhD from the University of Rochester, and his postdoctoral training with Dr. Richard Flavell from Yale University School of Medicine. In 2007, he started his independent research program at St. Jude Children’s Research Hospital, where he is currently a Member in the Department of Immunology, and Robert G. Webster Endowed Chair in Immunology. Dr. Chi’s research focuses on mechanisms of immune signaling and metabolism, in particular how mTOR and other signaling pathways interplay with metabolic programs in T cell fate decisions. His laboratory has discovered the critical importance of mTOR signaling, metabolism and autophagy in the differentiation and function of effector and regulatory T cells, the control of T cell quiescence and antigen-triggered exit from quiescence, and the regulation of autoimmune and infectious diseases and cancer. His research has also contributed to our understanding of the signaling and metabolic pathways in dendritic cell biology and the crosstalk between innate and adaptive immunity. More recently, his laboratory applies systems biology and immunology approaches, such as proteomics, metabolomics, single cell RNA-sequencing (scRNA-Seq), CRISPR screening and integrative network analysis, to reconstruct metabolic signaling circuits and identify new therapeutic targets in cancer and other immune-mediated diseases.
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