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Once thought of merely as byproducts of cellular metabolism, we now appreciate how metabolites can directly impact a myriad of processes, from signalling to gene expression, in cells. Cells adapt metabolism to allow ATP production and the redistribution of carbons to nucleotide, protein, and fatty acid syntheses to support their physiological functions. Metabolism can also influence cell state, with increasing evidence that changes in metabolite levels can affect both pathway regulation and gene expression, particularly through the effects of these metabolites on chromatin modifications. One example driven by genetic mutations is the role played by “oncometabolites,” which can impact the activity of enzymes that control epigenetic state. Such crosstalk between metabolism and epigenetics appears to be bi-directional, with multiple epigenetic enzymes acting as rheostats to readjust metabolism following nutrient changes. More recent studies determined that alterations in the microbiome influence availability of metabolites, in turn affecting signaling, cell proliferation, and chromatin. Lastly, changes in metabolites with age can impact both Sirtuins and PARP enzymes, influencing diverse pathways, including epigenetics and DNA repair.

This meeting will bring together scientists studying metabolites and their signaling properties and how they affect many aspects of health, including aging and cancer.

Topics:

  • Metabolite Regulation of Epigenetics and Gene Expression
  • Metabolites and Signaling
  • Metabolites in Cancer
  • Metabolites in Organismal Physiology and Aging
  • Metabolites and the Microbiota
Register Now Submit Abstract View Program
Keynote Speaker
Francis Collins

Featured Speaker

Speaker
Organizers
  • Raul Mostoslavsky, MGH Cancer Center, Harvard Medical School & The Broad Institute, USA
  • Kathryn Wellen, Perelman School of Medicine, University of Pennsylvania, USA
  • Matt Beymer, Editor, Trends in Endocrinology and Metabolism
  • Christine Cosma, Scientific Editor, Current Biology
  • Allyson Evans, Scientific Editor, Molecular Cell
Supporting Publications

Sponsor
 
AdipoGen
Elsevier Family Support Awards
 
Elsevier


Metabolites as Signaling Molecules
Forthcoming Cell Symposia View all
Metabolites as Signaling Molecules
Translation of Stem Cells to the Clinic: Challenges and Opportunities December 2 - 4, 2018
Cedars-Sinai, Los Angeles, CA, USA
Single Cells: Technology to Biology
Single Cells: Technology to Biology February 24-26, 2019
Singapore
Exercise Metabolism
Exercise Metabolism
May 5-7, 2019
Sitges, Spain
Single Cells: Technology to Biology
Regulatory RNAsMay 12–14, 2019
Berlin, Germany

Previous SymposiaView all
Cell-NERF Symposium: Neurotechnologies
September 30 - October 2, 2018
Leuven, Belgium 
TCGA Legacy: Multi-Omic Studies in Cancer
September 27 - 29, 2018
Washington, DC, USA 
Aging and Metabolism
September 23 - 25, 2018
Sitges, Spain
Translational Immunometabolism
June 24 - 26, 2018
Basel, Switzerland