Dr. W. Lee Kraus is the Director of the Cecil H. and Ida Green Center for Reproductive Biology Sciences at University of Texas South Western Medical Center. He is also Professor and Vice Chair for Basic Sciences in the Department of Obstetrics and Gynecology, and Professor of Pharmacology. Dr. Kraus received his Ph.D. in 1994 from the University of Illinois, Urbana-Champaign, where he studied gene regulation by steroid hormone signaling pathways. He completed his postdoctoral work at UC San Diego in 1998, where he studied the mechanisms of estrogen-regulated transcription from chromatin. Dr. Kraus was on the faculty at Cornell University in Ithaca, NY from 1999 to 2010, rising through the ranks to full professor. Since July 2010, he has been at UT Southwestern.
Dr. Kraus’ research has led to new information about the connections between hormone-regulated gene expression and the gene-regulating effects of chromatin, which has implications for understanding and treating breast cancers. His recent work has helped to characterize the estrogen-regulated transcriptome and identify thousands of novel non-coding RNAs. It has also led to some surprising new conclusions about the activity of poly(ADP-ribose) polymerase-1 (PARP-1), an NAD+-regulated nuclear factor that connects cellular NAD+ levels to nuclear signaling, chromatin structure, and gene expression.
Dr. Kraus has served as an editor for Molecular Endocrinology and Molecular Cancer Research. He is the founding organizer of the Cold Spring Harbor Laboratory meeting on the PARP family and has been an organizer of two Keystone Conferences on nuclear receptors. He has been recognized for his outstanding research by the Endocrine Society with the Richard E. Weitzman Memorial Award for research excellence is 2007 and the Ernst Oppenheimer Award for research excellence in 2014. Dr. Kraus holds the Cecil H. and Ida Green Distinguished Chair in Reproductive Biology Sciences at UT Southwestern Medical Center.
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