Speaker Articles

Take a look at what our speakers have published recently and chat with them about their work in Sitges, Spain this coming September.

Keynote Speakers

Ruslan Medzhitov, Yale School of Medicine, USA
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

Carla Shatz, Stanford University, USA
Blocking PirB up-regulates spines and functional synapses to unlock visual cortical plasticity and facilitate recovery from amblyopia
Synapse elimination and learning rules co-regulated by MHC class I H2-Db


Diana Bautista, University of California, Berkeley, USA
HTR7 Mediates Serotonergic Acute and Chronic Itch
Why we scratch an itch: the molecules, cells and circuits of itch

Burkhard Becher, University of Zurich, Switzerland
Dysregulation of the Cytokine GM-CSF Induces Spontaneous Phagocyte Invasion and Immunopathology in the Central Nervous System
Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

Marco Colonna, Washington University School of Medicine, USA
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Transcriptional programs define molecular characteristics of innate lymphoid cell classes and subsets

Josep Dalmau, IDIBAPS/University of Barcelona, Spain and University of Pennsylvania, USA
Encephalitis with refractory seizures, status epilepticus, and antibodies to the GABAA receptor: a case series, characterisation of the antigen, and analysis of the effects of antibodies

Marc Freeman, Oregon Health & Science University, USA
Age-Dependent TDP-43-Mediated Motor Neuron Degeneration Requires GSK3, hat-trick, and xmas-2Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

Sonia Garel, École Normale Supérieure, France
Reallocation of Olfactory Cajal-Retzius Cells Shapes Neocortex Architecture
Microglia Modulate Wiring of the Embryonic Forebrain

Florent Ginhoux, Singapore Immunology Network, Singapore
Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species Identification of cDC1- and cDC2-committed DC progenitors reveals early lineage priming at the common DC progenitor stage in the bone marrow
C-Myb+ Erythro-Myeloid Progenitor-Derived Fetal Monocytes Give Rise to Adult Tissue-Resident Macrophages

Christopher Glass, University of California, San Diego, USA
SREBP1 Contributes to Resolution of Pro-inflammatory TLR4 Signaling by Reprogramming Fatty Acid Metabolism
Tissue damage drives co-localization of NF-κB, Smad3, and Nrf2 to direct Rev-erb sensitive wound repair in mouse macrophages

Johanna Joyce, Ludwig Institute for Cancer Research/ University of Lausanne, Switzerland
Macrophage Ontogeny Underlies Differences in Tumor-Specific Education in Brain Malignancies
STAT3 and STAT6 Signaling Pathways Synergize to Promote Cathepsin Secretion from Macrophages via IRE1α Activation
The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas

Jonathan Kipnis, University of Virginia School of Medicine, USA
Unexpected role of interferon-γ in regulating neuronal connectivity and social behaviour
The Glia-Derived Alarmin IL-33 Orchestrates the Immune Response and Promotes Recovery following CNS Injury
Methyl-CpG Binding Protein 2 Regulates Microglia and Macrophage Gene Expression in Response to Inflammatory Stimuli

Robyn Klein, Washington University School of Medicine, USA
A complement–microglial axis drives synapse loss during virus-induced memory impairment

Shane Liddelow, Stanford University, USA
Neurotoxic reactive astrocytes are induced by activated microglia
SnapShot: Astrocytes in Health and Disease

Dan Littman, Skirball Institute, New York University School of Medicine, USA
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Sarkis Mazmanian, California Institute of Technology, USA
The Central Nervous System and the Gut Microbiome
Gene-microbiota interactions contribute to the pathogenesis of inflammatory bowel disease

Marco Prinz, University of Freiburg, Germany (Co-organizer)
Origin, fate and dynamics of macrophages at central nervous system interfaces
Brain Endothelial- and Epithelial-Specific Interferon Receptor Chain 1 Drives Virus-Induced Sickness Behavior and Cognitive Impairment

Francisco Quintana, Brigham and Women's Hospital, Harvard Medical School, USA
Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
System-wide Analysis of the T Cell Response

Richard Ransohoff, Biogen, USA
T cell–intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling

Larry Steinman, Stanford University, USA
Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2

Beth Stevens, Children's Hospital Boston, Harvard University, USA
Complement and microglia mediate early synapse loss in Alzheimer mouse models
Microglia: Dynamic Mediators of Synapse Development and Plasticity

Li-Huei Tsai, Massachusetts Institute of Technology, USA
Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes Gamma frequency entrainment attenuates amyloid load and modifies microglia


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