Kaspar is developing microscopes to track the synaptic activity patterns of single cortical neurons in great detail. Existing tools for monitoring synaptic activity are limited by tradeoffs between recording volume, speed, and sensitivity to brain movement. Kaspar's lab is applying concepts from compressive sensing to more efficiently use the limited bandwidth of imaging methods. They have developed a two-photon microscope that records from hundreds of synapses at kHz framerates in awake mice. Their goal is to better understand computation in cortical neurons by recording from every synapse on neurons at high speed during rich behaviors.
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