The laboratory of Dr Domingos focuses on neuroimmune mechanisms underlying obesity. Using optogenetics and multiphoton microscopy, among other tools, the laboratory of Dr Domingos has recently discovered a direct connection between adipocytes and the sympathetic nervous system (SNS) (Cell, 2015). Moreover, they showed that this SNS neuro-adipose junction mediates fat mass reduction (Cell, 2015, Nature Comm. 2017). Thus direct and targeted pharmacologic activation of sympathetic inputs to adipose tissues could represent a novel strategy for the induction of fat loss and a new anti-obesity therapy that would circumvent the challenges of drug delivery to the brain. More recently, the Domingos lab identified a molecular mechanism by which a specialized population of immune cells regulates the output of sympathetic neurons, and that is critical in obesity (Nature Medicine, in press). Howard Hughes Medical Institute, the Welcome Trust, the Human Frontiers Science Program, the European Molecular Biology Organization, and the Gulbenkian Foundation fund the laboratory of Dr Domingos. She has undergraduate training in mathematics, doctoral training in neurobiology mentored by Prof. Dr Leslie Vosshall and postdoctoral training in metabolism mentored by Prof. Dr Jeffrey Friedman, both at the Rockefeller University.
1999 BSc in Mathematics, Lisbon University, PT
2005 PhD in Neurobiology with Leslie Vosshall at Rockefeller University, New York, USA.
2006 Postdoc in Metabolism with Jeffrey Friedman at The Rockefeller University, New York, U.S.A.
2013 Principal Investigator of the Obesity Laboratory, at Instituto Gulbenkian de Ciência (IGC), Oeiras, PT
1. Zeng W*, Pirzgalska RM*; Pereira MMA; Kubasova N; Barateiro A; Seixas E; Lu YH; Kozlova A; Voss H; Martins GG; Friedman JM, Domingos AIψ (2015). Sympathetic Neuro-Adipose Connections Mediate Leptin-Driven Lipolysis. Cell.163(1):84–94, doi: http://dx.doi.org/10.1016/j.cell.2015.08.055.
—Johan Ruud & Jens Bruening (2015). Metabolism: Light on leptin link to lipolysis. Nature
—Natasha Bray (2015). Zapping fat in WAT, Nature Reviews Neuroscience
—News and Views (2015). A closer look at the nerves that slim down your fat cells, Science
—Luis Varela, Tamas L. Horvath (2015). A Sympathetic View on Fat by Leptin, Cell
2. Pereira MMA, Mahú I, Seixas E, Martinéz-Sánchez N, Kubasova N, Pirzgalska RM, Cohen P, Dietrich MO, López M, Bernardes GJL, Domingos, AIψ A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages. (2017) Nature Communications. 8:15673. doi: 10.1038/ncomms15673
3. Roksana M. Pirzgalska*, Elsa Seixas*, Jason S. Seidman, Verena M. Link, Noelia Martinez Sanchez, Inês Mahu, Raquel Mendes, Vitka Gres, Nadiya Kubasova, Imogen Morris, Bernardo A. Arús, Chelsea M. Larabee, Miguel Vasques, Francisco Tortosa, Ana L. Sousa, Sathyavathy Anandan, Erin Tranfield, Maureen K. Hahn, Matteo Iannacone, Nathanael J. Spann, Christopher K. Glass, Ana I. Domingosψ. Sympathetic neuron-associated macrophages contribute to obesity by importing and metabolizing norepinephrine. In press, Nature Medicine ψ corresponding author: * co-authors
« Go Back