Speakers articles

Take a look at what our Aging and Metabolism speakers have published recently and chat with them about their work in Sitges, Spain.

Keynote Speakers

Nir Barzilai, Albert Einstein College of Medicine, USA
System-wide Benefits of Intermeal Fasting by Autophagy

Linda Partridge, Max Planck Institute for Biology of Ageing, Germany
Intestinal Fork Head Regulates Nutrient Absorption and Promotes Longevity
Pseudo-acetylation of multiple sites on human Tau proteins alters Tau phosphorylation and microtubule binding, and ameliorates amyloid beta toxicity
Small nucleoli are a cellular hallmark of longevity

Speakers

Rozalyn Anderson, University of Wisconsin-Madison, USA
Aging and Caloric Restriction Research: A Biological Perspective With Translational Potential
Caloric restriction improves health and survival of rhesus monkeys

Jens Brüning, The Max Planck Institute for Metabolism Research, Germany
A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-induced insulin resistance in skeletal muscle
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
The Sense of Smell Impacts Metabolic Health and Obesity.
IL-6/Stat3-Dependent Induction of a Distinct, Obesity-Associated NK Cell Subpopulation Deteriorates Energy and Glucose Homeostasis
Temporal and tissue-specific requirements for T-lymphocyte IL-6 signalling in obesity-associated inflammation and insulin resistance
IL-6 Improves Energy and Glucose Homeostasis in Obesity via Enhanced Central IL-6 trans-Signaling.
Inhibition of P2Y6 Signaling in AgRP Neurons Reduces Food Intake and Improves Systemic Insulin Sensitivity in Obesity

Judith Campisi, Buck Institute for Research on Aging and Lawrence Berkeley National Laboratory, USA
Unmasking Transcriptional Heterogeneity in Senescent Cells
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Cell

Andrew Dillin, University of California, Berkeley, USA
"High-Throughput Characterization of Region-Specific Mitochondrial Function and Morphology"
The Sense of Smell Impacts Metabolic Health and Obesity
Neuroendocrine Coordination of Mitochondrial Stress Signaling and Proteostasis

Shin-ichiro Imai, Washington University School of Medicine, USA
Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice
NAMPT-Mediated NAD(+) Biosynthesis Is Essential for Vision In Mice.
NAMPT-Mediated NAD(+) Biosynthesis in Adipocytes Regulates Adipose Tissue Function and Multi-organ Insulin Sensitivity in Mice

Cynthia Kenyon, Calico, USA
A lysosomal switch triggers proteostasis renewal in the immortal C. elegans germ lineage
How a Mutation that Slows Aging Can Also Disproportionately Extend End-of-Life Decrepitude
Deep Proteome Analysis Identifies Age-Related Processes in C. elegans.
Reversible Age-Related Phenotypes Induced during Larval Quiescence in C. elegans

Valter D. Longo, The University of Southern California, USA
Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes
Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice

Emmanuelle Passegué, Columbia University Medical Center, USA
Myeloid progenitor cluster formation drives emergency and leukaemic myelopoiesis
The lung is a site of platelet biogenesis and a reservoir for haematopoietic progenitors
Autophagy maintains the metabolism and function of young and old stem cells

John Sedivy, Brown University, USA
Reduced expression of MYC increases longevity and enhances healthspan

Manuel Serrano, Institute for Research in Biomedicine, Spain
Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis
p21Cip1 plays a critical role in the physiological adaptation to fasting through activation of PPARα

P. Eline Slagboom, Leiden University Medical Centre, Netherlands
The effect of standardized food intake on the association between BMI and 1H-NMR metabolites
Genetic and environmental influences interact with age and sex in shaping the human methylome

Timothy Spector, Kings College London, UK
Obligatory and facilitative allelic variation in the DNA methylome within common disease-associated loci

Yousin Suh, Albert Einstein College of Medicine, USA
Genetic evidence for common pathways in human age-related diseases

Dario Riccardo Valenzano, Max Planck Institute for Biology of Ageing, Germany
Regulation of life span by the gut microbiota in the short-lived African turquoise killifish

Cornelia M. Weyand, Stanford University, School of Medicine, USA
Metabolic control of the scaffold protein TKS5 in tissue-invasive, proinflammatory T cells
The microvascular niche instructs T cells in large vessel vasculitis via the VEGF-Jagged1-Notch pathway
Deficient Activity of the Nuclease MRE11A Induces T Cell Aging and Promotes Arthritogenic Effector Functions in Patients with Rheumatoid Arthritis

Tony Wyss-Coray, Stanford University, USA
Activation of the STING-Dependent Type I Interferon Response Reduces Microglial Reactivity and Neuroinflammation
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice