Speaker articles

Take a look at what our esteemed speaker have published recently and discuss their research with them in Seattle in November.


Joan Massagué, Memorial Sloan Kettering Cancer Center, USA
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis

Caroline Robert, Institute Gustave-Roussy, France
Translational control of tumor immune escape via the eIF4F-STAT1-PD-L1 axis in melanoma


Eduard Batlle, IRB, Spain
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

Thomas Brabletz, Friedrich-Alexander University, Germany
Non-redundant functions of EMT transcription factors

Kevin Brindle, Cambridge University, UK
Measurement of Plasma Cell-Free Mitochondrial Tumor DNA Improves Detection of Glioblastoma in Patient-Derived Orthotopic Xenograft Models

Karin de Visser, Netherlands Cancer Institute, The Netherlands
Therapeutic targeting of macrophages enhances chemotherapy efficacy by unleashing type I interferon response

Ayelet Erez, Weizmann Institute, Israel
Urea Cycle Dysregulation Generates Clinically Relevant Genomic and Biochemical Signatures

Tom Gajewski, University of Chicago, USA
WNT/β-catenin Pathway Activation Correlates with Immune Exclusion across Human Cancers

Cyrus Ghajar, Fred Hutchinson Cancer Research Center, USA
Targeting the perivascular niche sensitizes disseminated tumour cells to chemotherapy

Philip Greenberg, Fred Hutchinson Cancer Research Center/University of Washington, USA
Generation of higher affinity T cell receptors by antigen-driven differentiation of progenitor T cells in vitro

Sui Huang, Institute for Systems Biology, USA
Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

David Hyman, Memorial Sloan Kettering Cancer Center, USA
Efficacy of MEK inhibition in patients with histiocytic neoplasms

Charles Mullighan, St. Jude Children’s Hospital, USA
Genomic subtyping and therapeutic targeting of acute erythroleukemia

Kornelia Polyak, Dana-Farber Cancer Institute, USA
TRPS1 Is a Lineage-Specific Transcriptional Dependency in Breast Cancer

Jeff Rathmell, Vanderbilt University, USA
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism 

Alice Shaw, Massachusetts General Hospital, USA
Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-positive Advanced Non-small-cell Lung Cancer in the Global Phase III ALEX Study

Celeste Simon, University of Pennsylvania, USA
Hif1α Deletion Limits Tissue Regeneration via Aberrant B Cell Accumulation in Experimental Pancreatitis

Matthew Walter, Washington University in St. Louis, USA
Discriminating a common somatic ASXL1 mutation (c.1934dup; p.G646Wfs*12) from artifact in myeloid malignancies using NGS

Zena Werb, University of California San Francisco, USA
Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers 

Cathy Wu, Dana-Farber Cancer Institute, USA
Integrative annotation and knowledge discovery of kinase post-translational modifications and cancer-associated mutations through federated protein ontologies and resources


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