Thomas Brabletz is Professor for Molecular Oncology and Chair of the Dept. of Experimental Medicine, University Erlangen, Germany. Focusing on malignant cancer progression, in particular mechanisms of invasion and metastasis, he aims to integrate basic and clinically relevant cancer research. He proposed a concept of transient rounds of EMT and MET, resulting in aberrant cellular plasticity and the generation of ‘Migrating cancer stem cells’ as driving force of metastasis. Currently his major interests are in uncovering underlying mechanisms, such as feedback loops between EMT-inducers, oncogenic pathways and microRNAs, as basis for novel therapeutic strategies to fight cancer metastasis.
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