Speaker articles

Take a look at what some of our Hallmarks of Cancer speakers have published recently and chat with them about their work in San Diego, USA.

Keynote speakers

Carl JuneUniversity of Pennsylvania, Philadelphia, USA
The immunostimulatory RNA RN7SL1 enables CAR-T cells to enhance autonomous and endogenous immune function

Jennifer WargoThe University of Texas MD Anderson Cancer Center, Houston, USA
Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade

Speakers

Timothy ChanCleveland Clinic, Cleveland, USA
Single-cell sequencing links multiregional immune landscapes and tissue-resident T cells in ccRCC to tumor topology and therapy efficacy

Lisa CoussensOregon Health & Science University, USA
Safety and Efficacy of Pembrolizumab in Combination with Acalabrutinib in Advanced Head and Neck Squamous Cell Carcinoma: Phase 2 Proof-of-Concept Study

Maximilian DiehnStanford University, Stanford, USA
Enhanced detection of minimal residual disease by targeted sequencing of phased variants in circulating tumor DNA

Philip GreenbergFred Hutchinson Cancer Research Center, Seattle, USA
Engineering adoptive T cell therapy to co-opt Fas ligand-mediated death signaling in ovarian cancer enhances therapeutic efficacy

John HaanenThe Netherlands Cancer Institute, Amsterdam, Netherlands
Discontinuation of anti-PD-1 monotherapy in advanced melanoma—Outcomes of daily clinical practice

Han LiangThe University of Texas MD Anderson Cancer Center, Houston, USA
A functional genomic approach to actionable gene fusions for precision oncology

Howard Hang Scripps Research, San Diego, USA
Enterococcus peptidoglycan remodeling promotes checkpoint inhibitor cancer immunotherapy

Rob KnightUniversity of California at San Diego, San Diego, USA
Assessment of the microbiome during bacteriophage therapy in combination with systemic antibiotics to treat a case of staphylococcal device infection

Miriam MeradIcahn School of Medicine at Mount Sinai in New York City, New York, USA
Single-cell analysis of human non-small cell lung cancer lesions refines tumor classification and patient stratification

Antoni RibasUniversity of California at Los Angeles, Los Angeles, USA
Overcoming PD-1 blockade resistance with CpG-A toll-like receptor 9 agonist vidutolimod in patients with metastatic melanoma

Stanley RiddellFred Hutchinson Cancer Research Center, Seattle, USA
Comparative analysis of TCR and CAR signaling informs CAR designs with superior antigen sensitivity and in vivo function

Andrea SchietingerMemorial Sloan Kettering Caner Center, USA
TOX is a critical regulator of tumour-specific T cell differentiation

Ravid StraussmanWeizmann Institute of Science, Rehovot, Israel
Ex vivo organotypic cultures for synergistic therapy prioritization identify patient-specific responses to combined MEK and Src inhibition in colorectal cancer

Charles SwantonThe Francis Crick Institute, London, UK
Meta-analysis of tumor- and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition

Suzanne TopalianJohns Hopkins Medicine, Baltimore, USA
The genetic evolution of treatment-resistant cutaneous, acral, and uveal melanomas

David TuvesonCold Spring Harbor Laboratory, New York, USA
Inhibition of hedgehog signaling alters fibroblast composition in pancreatic cancer

Karin de VisserThe Netherlands Cancer Institute, Amsterdam, Netherlands
Tumor-educated Tregs drive organ-specific metastasis in breast cancer by impairing NK cells in the lymph node niche

Catherine WuDana-Farber Cancer Institute, Boston, USA
Unannotated proteins expand the MHC-I-restricted immunopeptidome in cancer

Laurence ZitvogelInstitut Gustave Roussy, Villejuif, France
Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer

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