Amy K Walker, PhD lab has a long-standing interest in how genes are regulated during biological transitions. During my graduate work at SUNY Stonybrook with Dr. Paula Enrietto, I studied how a transcription factor related to NFkB regulated genes to control oncogenic transformation in chick hematopoietic cells. In my postdoctoral training with Dr. Keith Blackwell (Harvard Medical School), I studied how the general transcriptional machinery had specific roles during C. elegans embryonic development. Later, working with Dr. Anders Näär at Mass General, I became interested in how transcriptional and metabolic regulation were linked. In my own lab at UMASS Medical School, I have studying how levels of the methyl donor S-adenosylmethionine (SAM) can influence how a master transcriptional regulator of lipogenesis functions as well as how SAM levels can impact histone methylation and stress induced gene expression.
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