Speakers articles

Take a look at what our Cell Symposium: Metabolites as Signaling Molecules speakers have published recently and chat with them about their work in Seattle, WA, USA.

Keynote Speakers

Ralph DeBerardinis, UT Southwestern Medical School, Dallas, USA
Lactate Metabolism in Human Lung Tumors

Celeste Simon, University of Pennsylvania, USA
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers

Featured Speaker


Donita Brady, Perelman School of Medicine, University of Pennsylvania, USA
Wnt5a signaling induced phosphorylation increases APT1 activity and promotes melanoma metastatic behavior

Andrew Dillin, Department of Molecular and Cell Biology, University of California Berkeley, USA
The Sense of Smell Impacts Metabolic Health and Obesity

Sarah-Marie Fendt, VIB-KU Leuven Center for Cancer Biology, Belgium
Proline metabolism supports metastasis formation and could be inhibited to selectively target metastasizing cancer cells

Eyal Gotttlieb, Technion Integrated Cancer Center, Israel Institute of Technology, Israel
Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

Marcia Haigis, Department of Cell Biology, Harvard Medical School, USA
Small-Molecule Screen Identifies De Novo Nucleotide Synthesis as a Vulnerability of Cells Lacking SIRT3

Barbara Kahn, Beth Israel Deaconess Medical Center, Harvard Medical School, USA
Palmitic Acid Hydroxystearic Acids Activate GPR40, Which Is Involved in Their Beneficial Effects on Glucose Homeostasis

Lee Kraus, Cecil H. and Ida Green Center for Reproductive Biology Sciences, UT Southwestern Medical Center, USA
Catalytic-Independent Functions of PARP-1 Determine Sox2 Pioneer Activity at Intractable Genomic Loci
Metabolic regulation of transcription through compartmentalized NAD+ biosynthesis

Mitch Lazar, Perelman School of Medicine, University of Pennsylvania, USA
Rev-erbα dynamically modulates chromatin looping to control circadian gene transcription

Jason Locasale, Department of Pharmacology and Cancer Biology, Duke University School of Medicine, USA
Serine Availability Influences Mitochondrial Dynamics and Function through Lipid Metabolism

Raul Mostoslavsky, MGH Cancer Center, Harvard Medical School, USA
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality

Luke O’Neill, Trinity Biomedical Sciences Institute, Trinity College Dublin, The University of Dublin, Ireland
Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

Federico Rey, Department of Bacteriology, University of Wisconsin-Madison, USA
Metabolic, Epigenetic, and Transgenerational Effects of Gut Bacterial Choline Consumption

Benjamin Tu, Department of Biochemistry, University of Texas Southwestern Medical Center, USA
A Metabolic Function for Phospholipid and Histone Methylation

Amy Walker, Department of Molecular Medicine, University of Massachusetts Medical School, USA
Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation

Kathryn Wellen, Perelman School of Medicine, University of Pennsylvania, USA
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination

Yingming Zhao, The Ben May Department for Cancer Research, The University of Chicago, USA
Landscape of the regulatory elements for lysine 2-hydroxyisobutyrylation pathway
EP300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis

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Supporting Publications
Elsevier Family Support Awards