Ulrich Brandt is Professor for Mitochondrial Molecular Medicine at the Radboud University Medical Center in Nijmegen, The Netherlands, International Faculty Professor at the University Cologne, Germany, and Adjunct Professor for Biochemistry at the Cluster of Excellence “Macromolecular Complexes” of the Goethe‐University, Frankfurt am Main, Germany. Dr. Brandt graduated in Biochemistry from the Eberhard‐Karls University in Tübingen and obtained his PhD from the Ludwig‐Maximilians University in Munich for his research on specific inhibitors of the mitochondrial cytochrome bc1 complex and functional aspects of cytochrome c oxidase. Between 1991 and 1993, he was a Feodor‐Lynen fellow of the Humboldt Foundation at the Dartmouth Medical School, New Hampshire, where he started working in the field of yeast genetics. In 1993, he returned to Germany to the Johann‐Wolfgang‐Goethe University in Frankfurt am Main, where he became a Docent in 1994 and a Professor of Biochemistry in 1996. From 1997 to 2009 Dr. Brandt was Deputy‐Director and from 2009‐2012 Director of the Centre of Biological Chemistry at the Medical Faculty, Goethe‐University. And from 1997‐2012 he served as Secretary General of the German Society for Biochemistry and Molecular Biology (GBM). He is founding member of the Cluster of Excellence “Macromolecular Complexes” of the Goethe‐University. Since 2012 he has been Editor‐in‐Chief of the BBA and from 2005‐2013 he was Executive Editor of BBA Bioenergetics.
Dr. Brandt’s research interest focuses on the structure and function of respiratory chain complexes. His group established the strictly aerobic yeast Yarrowia lipolytica as a powerful model to study mitochondrial complex I leading to a series of discoveries especially on the ubiquinone and inhibitor binding domain. In recent years he published the X‐ray structure of this giant membrane integral multiprotein complex shedding light on the still enigmatic molecular mechanism of energy conversion by this redox driven proton pump. In 2012 his group established complexome profiling and has now developed it into a powerful proteomics approach to study the composition and dynamics of multiprotein complexes. This allowed deciphering the pathway by which the 44 different subunits of mitochondrial complex I are assembled and led to the discovery of several assembly factors supporting this process. Dr. Brandt has also studied numerous other aspects of mitochondria biology bridging classical bioenergetics and the exciting recent developments that featuring mitochondria as key players in apoptosis, degenerative disorders and ageing.
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