Nadine Cerf-Bensussan, MD, PhD, is Research Director at Inserm, head of the laboratory of Intestinal Immunity at Institute Imagine and Université Paris Cité, and coordinator of Inserm Transversal Program on Microbiota. Her team has contributed to show the key role of Segmented Filamentous Bacteria in the post-natal maturation of the gut immune barrier. Studies in celiac disease have established how autoimmune-like inflammation driven by dietary gluten can ultimately lead to lymphomagenesis developing from gut intraepithelial lymphocytes carrying gain of function JAK1 or STAT3 mutations. Recent work in monogenic intestinal disorders aims at hierarchizing the mechanisms indispensable for human gut homeostasis and translating results into improved care of these rare diseases but also better understanding of frequent polyfactorial intestinal inflammatory diseases. She was awarded an ERC Advanced grant in 2013, the Distinguished Scientific Achievement Award from the Society for Mucosal Immunology in 2017, the Maki Celiac Tampere Prize in 2018 and the Grand Prix Inserm in 2023.
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