Sophie Ugolini is a research director at the at the French National Institute for Health and Medical Research(INSERM) and the head of the Neural Regulation of Immunity laboratory at the Marseille-Luminy Immunology Centre (CIML), France. Her principal research goal is to understand how innate and adaptive immune responses are regulated to establish potent antimicrobial and antitumor defense without inducing excessive inflammation and auto-immunity. She has used natural killer (NK) cells as a cell model for studying the mechanisms of immune tolerance and responsiveness from the molecular to the cellular and systemic levels. Her team has analysed the mechanisms of immune defense in various infectious and cancer models, in both humans and mice, by genetic and functional approaches.
More recently, she has been exploring the interactions between the nervous and immune systems. In particular, her laboratory has identified novel neuroimmune pathways playing a crucial role in the regulation of infectious diseases, inflammation and tissue repair. Among other distinctions, Sophie Ugolini received an European Research Council (ERC) award, the “Duquesne award” from the Ligue nationale contre le cancer, the “Research award” from INSERM and the “Dandrimont-Bénicourt award” from the Institut de France.
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