Dr. Pascual is Director of the Drukier Institute for Children’s Health and the Ronay A, Menschel Professor of Pediatrics at Weill Cornell Medical College in New York, NY. She is also the Program Director of an NIAID-funded Autoimmunity Center of Excellence and NIAMS-funded Center of Research Translation focused on Pediatric Lupus. Dr. Pascual is a pediatric rheumatologist interested in basic and translational immunology. Her research focuses on pediatric inflammatory and autoimmune diseases with the goals of translating laboratory findings into the identification of therapeutic targets and useful biomarkers. Her studies have contributed to the discovery that type I interferon (IFN) and interleukin 1 (IL-1) are important pathogenic players in Systemic Lupus Erythematosus (SLE) and systemic onset Juvenile Idiopathic Arthritis (sJIA), respectively. Using genomic approaches, her group is identifying novel pathways to target therapeutically as well as unique signatures to follow patients in the clinic and assess responses to therapy. Dr. Pascual and her colleagues have been at the forefront of clinical trials using IL-1 blockers in sJIA, which have shown remarkable clinical benefits in nearly 70% of patients.
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