Catriona Jamieson, UCSD, USA

Dr. Catriona Jamieson is a leading physician-scientist who discovered missplicing, RNA hyper-editing and splice isoform switching as mechanisms governing human cancer stem cell maintenance in selective niches. This pioneering cancer stem cell research has transformed therapies, including JAK2 and sonic hedgehog-inhibitor trials for myeloproliferative neoplasm and leukemia stem cell targeting. Her research and efforts lead to the 2019 FDA approval of fedratinib for the treatment of adult patients with intermediate-2 or high-risk primary or secondary Myelofibrosis. On April 8, 2022, she sent the first bioreactors with cancer organoids that detect activation of cancer stem cell properties in real-time into space as part of the Integrated Space Stem Cell Orbital Research (ISSCOR) Program. The purpose is to identify biomarkers for early detection and interventional leads, laying groundwork for future cancer stem cell research in space.

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