Xiangxi Wang, principal investigator and doctoral supervisor of the Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences. He received his bachelor’s degree in biotechnology from Sichuan University in 2009, and his doctor’s degree from the Institute of Biophysics, Chinese Academy of Sciences in June 2014. Since July 2014, he has been engaged in scientific research at the Institute of Biophysics, Chinese Academy of Sciences. He has conducted structural and functional studies of whole viral particles of viruses that are directly related to critical infectious diseases and their complexes with the neutralizing antibodies or key receptors, revealing the virus invasion mechanism and immune mechanism, and making a series of innovative findings. As a corresponding author (including co-corresponding author), he has published over 50 research papers, including Science (4), Nature (5), Cell (1), Cell Res (7), Nat Commun (5), PNAS (2), NATL SCI REV (2), Cell Host & Microbe and Nat Microbiol. All papers have been cited by SCI more than 6,000 times in the last five years. He won the first Zhong Nanshan Youth Science and Technology Innovation Award (2020), Tan Jiazhen Life Science Innovation Award (2021), Young Scientist Award of Chinese Academy of Sciences (2020), VCABIO Award for Biosciences (2020), National Youth Talent Support Program (2019), Creative Research Group Core Member of NSFC (2019) and Youth Talent Supporting Program (2015), etc. He led the research team to participate in the R&D of the SARS-CoV-2 inactivated vaccine and recombinant vaccine and applied the structural information and immune characteristics of the virus to the quality control during vaccine production, so as to improve the protection efficiency of the vaccine and the consistency among batches. Since the large-scale use of the vaccine, the team has been continuously tracing the immune mechanism of the vaccine, the protective effects of the vaccine for mutant strains and the virus characteristics of mutant strains, providing scientific basis for the formulation of COVID-19 prevention and control strategy. In addition, the development and application of high-resolution reconstruction method for "super large-scale particles" further extends the application scope of cryo-electron microscopy structure analysis, and it was revealed that the single particle reconstruction of giant virus particles or subcellular super large protein complexes could achieve near-atomic resolution, further promoting the progress and development of structural biology. The research findings were selected into "2020 Top Ten Scientific Advances in China", "2019 Top Ten Scientific Advances in China" and "2018 Top Ten Life Sciences Advances in China".
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