Anthony Letai, Dana-Farber Cancer Institute, USA
Anthony Letai

Anthony Letai received his MD and PhD at the University of Chicago, completing clinical training in Hematology and Oncology at Dana-Farber Cancer Institute. After a post-doc with Stanley Korsmeyer.  Since 2004 Dr. Letai has run a laboratory at Harvard Medical School and Dana-Farber Cancer Institute to study how apoptosis can be evaded by cancer cells. Key to these studies is a novel assay - BH3 profiling.  He has led efforts to translate BCL-2, BCL-XL, and MCL-1 antagonists into the clinic.  These include venetoclax, a BCL-2 antagonist approved by the FDA for CLL and AML and now being tested across nearly all blood cancers.  The laboratory is testing whether BH3 profiling can be used as a broad predictive biomarker to assign clinical cancer therapy.

Homepage: https://letailab.dana-farber.org/
Twitter: @ DrTonyLetai

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