Speakers articles

Take a look at what some of our speakers have published recently and chat with them about their work in Rehovot, Israel.

Keynote Speakers

James P. Allison, MD Anderson Cancer Center, USA
Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential
Intratumoral modulation of the inducible co-stimulator ICOS by recombinant oncolytic virus promotes systemic anti-tumour immunity
The future of immune checkpoint therapy

Ruslan Medzhitov, Yale University / Howard Hughes Medical Institute, USA
Opposing Effects of Fasting Metabolism on Tissue Tolerance in Bacterial and Viral Inflammation
The Effect of Sustained Inflammation on Hepatic Mevalonate Pathway Results in Hyperglycemia
Anti-inflammatory effect of IL-10 mediated by metabolic reprogramming of macrophages


Ido Amit, Weizmann Institute of Science, Israel
Dissecting Immune Circuits by Linking CRISPR-Pooled Screens with Single-Cell RNA-Seq
The Spectrum and Regulatory Landscape of Intestinal Innate Lymphoid Cells Are Shaped by the Microbiome
Microglia development follows a stepwise program to regulate brain homeostasis

David Artis, Weill Cornell Medicine, USA
Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation
Epithelial-intrinsic IKKα expression regulates group 3 innate lymphoid cell responses and antibacterial immunity
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity

Yasmine Belkaid, NIH, USA
Linking the Microbiota, Chronic Disease, and the Immune System
Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection
The influence of skin microorganisms on cutaneous immunity

Julie Magarian Blander, Weill Cornell Medicine, USA
Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs
Apoptosis in response to microbial infection induces autoreactive TH17 cells

Doreen Cantrell, University of Dundee, UK
Phosphoproteomic Analyses of Interleukin 2 Signaling Reveal Integrated JAK Kinase-Dependent and -Independent Networks in CD8(+) T Cells
Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy
The cytotoxic T cell proteome and its shaping by the kinase mTOR

Marco Colonna, Washington University St. Louis, USA
IL-15 sustains IL-7R-independent ILC2 and ILC3 development
Innate lymphoid cell function in the context of adaptive immunity
Transforming Growth Factor-β Signaling Guides the Differentiation of Innate Lymphoid Cells in Salivary Glands
TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

Pascale Cossart, Institut Pasteur, France
N-terminomics identifies Prli42 as a membrane miniprotein conserved in Firmicutes and critical for stressosome activation in Listeria monocytogenes
The Diverse Family of Arp2/3 Complexes

Jason Cyster, University of California San Francisco, USA
The Eph-related tyrosine kinase ligand Ephrin-B1 marks germinal center and memory precursor B cells
IgA production requires B cell interaction with subepithelial dendritic cells in Peyer's patches
EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

Ana Domingos, Instituto Gulbenkian de Ciência (IGC), Portugal
A brain-sparing diphtheria toxin for chemical genetic ablation of peripheral cell lineages
Sympathetic neuro-adipose connections mediate leptin-driven lipolysis

Eran Elinav, Weizmann Institute of Science, Israel
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
Persistent microbiome alterations modulate the rate of post-dieting weight regain
Microbiota-Modulated Metabolites Shape the Intestinal Microenvironment by Regulating NLRP6 Inflammasome Signaling

Brett Finlay, The University of British Columbia, Canada
Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body
Assembly, structure, function and regulation of type III secretion systems
Early infancy microbial and metabolic alterations affect risk of childhood asthma

Michael Fischbach, University of California San Francisco, USA
Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
Modulation of a Circulating Uremic Solute via Rational Genetic Manipulation of the Gut Microbiota
A biosynthetic pathway for a prominent class of microbiota-derived bile acids

Richard Flavell, Yale University, USA
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier
Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis
Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation

Jorge Henao-Mejia, University of Pennsylvania, USA
The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan

Kenya Honda, RIKEN, Japan
Development and maintenance of intestinal regulatory T cells
Th17 Cell Induction by Adhesion of Microbes to Intestinal Epithelial Cells

Lora Hooper, University of Texas Southwestern Medical Center, USA
Microbial Respiration and Formate Oxidation as Metabolic Signatures of Inflammation-Associated Dysbiosis
Antimicrobial defense of the intestine

Vijay Kuchroo, Harvard University, USA
Critical role of IRF1 and BATF in forming chromatin landscape during type 1 regulatory cell differentiation
The transcription factor musculin promotes the unidirectional development of peripheral Treg cells by suppressing the TH2 transcriptional program
RBPJ Controls Development of Pathogenic Th17 Cells by Regulating IL-23 Receptor Expression

Guido Kroemer, INSERM, Institut Gustave Roussy, France
Immunogenic cell death in cancer and infectious disease
Metabolic Control of Longevity
Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance

Eicke Latz, University of Bonn, Germany
NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain
Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming
Synergistic activation of Toll-like receptor 8 by two RNA degradation products

Dan Littman, NYU School of Medicine, USA
Actin Dynamics Regulates Dendritic Cell-Mediated Transfer of HIV-1 to T Cells
The microbiota in adaptive immune homeostasis and disease
DDX5 and its associated lncRNA Rmrp modulate TH17 cell effector functions
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses

Ofer Mandelboim, The Hebrew University of Jerusalem, Israel
An IL-23R/IL-22 Circuit Regulates Epithelial Serum Amyloid A to Promote Local Effector Th17 Responses
NK Cell Recognition of Candida glabrata through Binding of NKp46 and NCR1 to Fungal Ligands Epa1, Epa6, and Epa7
CEACAM1-Mediated Inhibition of Virus Production

Alberto Mantovani, Humanitas Clinical and Research Center, Italy
An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode
PTX3 is an extrinsic oncosuppressor regulating complement-dependent inflammation in cancer

Diane Mathis, Harvard Medical School, USA
The transcriptional regulator Aire binds to and activates super-enhancers
Aire Inhibits the Generation of a Perinatal Population of Interleukin-17A-Producing γδ T Cells to Promote Immunologic Tolerance
Poor Repair of Skeletal Muscle in Aging Mice Reflects a Defect in Local, Interleukin-33-Dependent Accumulation of Regulatory T Cells

Eric Pamer, Memorial Sloan Kettering Cancer Center, USA
Resurrecting the intestinal microbiota to combat antibiotic-resistant pathogens
Innate Lymphocyte/Ly6C(hi) Monocyte Crosstalk Promotes Klebsiella Pneumoniae Clearance
TLR-7 activation enhances IL-22-mediated colonization resistance against vancomycin-resistant enterococcus

Virginia Pascual, Weill Cornell Medical College, USA
Oxidized mitochondrial nucleoids released by neutrophils drive type I interferon production in human lupus
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients

Erika Pearce, Max Planck Institute of Immunobiology & Epigenetics, Germany
Mitochondrial Dynamics Controls T Cell Fate through Metabolic Programming
Emerging concepts of T cell metabolism as a target of immunotherapy
Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Fiona Powrie, Kennedy Institute of Reumatology, University of Oxford, UK
Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease
Emerging cytokine networks in colorectal cancer
T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine

Richard Ransohoff, Biogen Inc., USA
Microglial Physiology and Pathophysiology: Insights from Genome-wide Transcriptional Profiling
How neuroinflammation contributes to neurodegeneration
A polarizing question: do M1 and M2 microglia exist?

Philippe Sansonetti, Institut Pasteur, France
Growth and host interaction of mouse segmented filamentous bacteria in vitro
Apical invasion of intestinal epithelial cells by Salmonella typhimurium requires villin to remodel the brush border actin cytoskeleton

Robert Schreiber, Washington University St. Louis, USA
CANCER. The odds of immunotherapy success
Neoantigens in cancer immunotherapy

Eran Segal, Weizmann Institute of Science, Israel
Systematic Investigation of Transcription Factor Activity in the Context of Chromatin Using Massively Parallel Binding and Expression Assays
Massively Parallel Interrogation of the Effects of Gene Expression Levels on Fitness
Comparative genetics. Systematic discovery of cap-independent translation sequences in human and viral genomes

Michal Schwartz, Weizmann Institute of Science, Israel
PD-1 immune checkpoint blockade reduces pathology and improves memory in mouse models of Alzheimer's disease
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology

Padmanee Sharma, MD Anderson Cancer Center, USA
VISTA is an inhibitory immune checkpoint that is increased after ipilimumab therapy in patients with prostate cancer
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy
Interdependent IL-7 and IFN-γ signalling in T-cell controls tumour eradication by combined α-CTLA-4+α-PD-1 therapy


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