Mitochondria, historically known as the powerhouse of the cell, are increasingly recognized for their many other functions, with our understanding of their importance to cellular homeostasis and physiology constantly expanding and evolving. These complex organelles simultaneously act as signaling and sensing hubs, coordinating metabolic inputs and communicating not just within the cell but also systemically. Unsurprisingly, they are implicated in a broad range of diseases, and there is growing interest in how to target mitochondria therapeutically and the potential use of mitochondrial editing and transfer. 

This symposium will bring together scientists working on all aspects of this marvelous organelle, from basic bioenergetics all the way to disease. Starting with the fundamental mechanisms of how mitochondria work, their architecture, dynamics, and quality control pathways, to their integrated role in metabolism, stress responses, intra- and intercellular communication, and culminating in the contribution of mitochondria to disease and inflammation, as well as strategies for targeting these organelles.

We hope the diversity of topics and scientists will lead to stimulating discussion around the open questions, what we need to do to answer them, and the future for this exciting field.

Themes:

• Mitochondrial biochemistry and bioenergetics
• Mitochondrial homeostasis, quality control and stress signalling
• Mitochondria in metabolism
• Mitochondrial communication
• Mitochondria in inflammation and disease
• Mitochondrial tools and targeting